Attended a theatre school in Chicago with sisters Joan Cusack and Ann Cusack. The theatre school was run by the parents of his best friend, Jeremy Piven
Last name is pronounced Kyoo-sack.
The novel "Love In The Time Of Cholera" by author Gabriel Garcia Marquez is prominently referenced in two John Cusack movies (High Fidelity (2000) and Serendipity (2001).